注册 登录  
 加关注
   显示下一条  |  关闭
温馨提示!由于新浪微博认证机制调整,您的新浪微博帐号绑定已过期,请重新绑定!立即重新绑定新浪微博》  |  关闭

zliming2004的博客

新药研发与药物合成

 
 
 

日志

 
 
 
 

Crenolanib  

2015-06-18 11:25:31|  分类: 合成化学 |  标签: |举报 |字号 订阅

  下载LOFTER 我的照片书  |
Crenolanib is an oncolytic in phase II clinical trials at AROG Pharmaceuticals for the treatment of gastrointestinal stromal cancer (GIST) in patients with the D842V mutation in the PDGFRA gene and for the treatment of adult gliomas. St Jude Children's Research Hospital is evaluating the compound in phase I clinical trials for the treatment of children and young adults (18 months to 21 years) with newly diagnosed diffuse intrinsic pontine glioma or recurrent high-grade glioma.The compound had been in early clinical trials at Pfizer for the treatment of non-small cell lung cancer (NSCLC); however, development for this indication was discontinued in 2007. 

The drug candidate is a potent inhibitor of the angiogenic platelet-derived growth factor receptor (PDGFR) beta kinase, which also modulates tumor interstitial fluid pressure and influences cell growth, migration and survival. 

Crenolanib was jointly discovered through a collaboration between OSI Pharmaceuticals and Pfizer that was penned in April 1986, and renewed in April 1991 and April 1996. Since April 2001, when the collaboration was allowed to expire, Pfizer continues to develop the drug candidate. In 2010, crenolanib was licensed to AROG Pharmaceuticals by Pfizer. In 2012, orphan drug designation was assigned in the U.S. for the treatment of acute myeloid leukemia.
Phase Organization Condition
Phase IIAROG PharmaceuticalsGastrointestinal stromal tumor (GIST)
Phase IIAROG PharmaceuticalsLeukemia, acute myeloid
Phase IAROG PharmaceuticalsGlioma

Crenolanib - zliming2004 - zliming2004的博客

Crenolanib - zliming2004 - zliming2004的博客
 
Crenolanib - zliming2004 - zliming2004的博客

Patent NumberApplicantTitleConditionSubject Matter
WO 2004020431
US 2005124599
EP 1594858
JP 2006501309
 
Pfizer Products Inc.  Novel benzoimidazole derivatives useful as antiproliferative agentsCrenolanib - zliming2004 - zliming2004的博客  
Cancer
Crenolanib - zliming2004 - zliming2004的博客  
 
JP 2007516168
US 2005020625
WO 2004113322
 
Pfizer Inc.  Processes for the preparation of benzoimidazole derivativesCrenolanib - zliming2004 - zliming2004的博客  Crenolanib - zliming2004 - zliming2004的博客   
 
  评论这张
 
阅读(111)| 评论(0)
推荐 转载

历史上的今天

评论

<#--最新日志,群博日志--> <#--推荐日志--> <#--引用记录--> <#--博主推荐--> <#--随机阅读--> <#--首页推荐--> <#--历史上的今天--> <#--被推荐日志--> <#--上一篇,下一篇--> <#-- 热度 --> <#-- 网易新闻广告 --> <#--右边模块结构--> <#--评论模块结构--> <#--引用模块结构--> <#--博主发起的投票-->
 
 
 
 
 
 
 
 
 
 
 
 
 
 

页脚

网易公司版权所有 ©1997-2017